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When there are no complications, therapeutic phlebotomy usually takes 10 to 15 minutes to complete. It can be quick and easy for many individuals.
Serum ferritin is the most reliable method of monitoring patients who are receiving therapeutic phlebotomy. Patients with significantly high initial ferritin levels are greater than 1000 ng/ml and or more frequent phlebotomies should have their serum ferritin monitored every 2 to 3 months.
According to Adams et al., after reaching these targets, therapeutic phlebotomy should be performed every 2 to 4 months to maintain the serum ferritin between 50 ng/mL and 100 ng/mL51.
Therapeutic phlebotomy is currently indicated for the treatment of hemochromatosis, polycythemia vera, porphyria cutanea tarda, sickle cell disease, and NAFLD with hyperferritinemia.
Therapeutic phlebotomy may be indicated for hemochromatosis, polycythemia vera, porphyria cutanea tarda, and polycythemia secondary to arterio-venous fistulae, cyanotic congenital heart disease or cor pulmonale.

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Who Performs a Therapeutic Phlebotomy? A trained phlebotomist performs the procedure to remove the blood. A phlebotomist will typically perform this therapy in a medical office, hospital, or even a community blood service center.
During a phlebotomy, approximately one pint of blood will be taken from a vein in your arm. The actual process takes approximately 30-45 minutes. After the procedure is completed, it will be necessary for you to rest for 15-20 minutes and drink some juice or water. The entire procedure takes about one hour.
Therapeutic phlebotomy is a blood draw that's done to treat a medical problem, such as having too much iron in your blood. With therapeutic phlebotomy, more blood is drawn than during a regular blood draw. Your doctor will decide how much blood will be drawn based on the reason you're having the procedure.
Your doctor will decide how much blood will be drawn based on the reason you're having the procedure. If you can, it's helpful to drink more liquids than usual before your therapeutic phlebotomy procedure. Aim to drink 8 to 10 (8-ounce) glasses of liquids for 1 day before your procedure.
Your doctor will decide how much blood will be drawn based on the reason you're having the procedure. If you can, it's helpful to drink more liquids than usual before your therapeutic phlebotomy procedure. Aim to drink 8 to 10 (8-ounce) glasses of liquids for 1 day before your procedure.

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