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XYWAV and XYREM will be dispensed only by the REMS Certified Pharmacy.
Anyone who takes XYWAV or XYREM should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least 6 hours after taking XYWAV or XYREM.
It is recommended that you do not drive when you first start using a new medicine until you know how that drug affects you. You also need to be aware that some over- the-counter medicines and herbal supplements can make it difficult for you to drive safely. Talk to your pharmacist. Get to know your pharmacist.
Nausea, dizziness, bloating, headache, urinary issues, loud snoring, unusual wake gain or loss, balance problems, back pain, increased sweating, vomiting or abdominal pain, dry mouth, abnormal dreams, seeing, hearing, or feeling things that are not there, sleepiness, tremor, thoughts of killing oneself, tingling of the
Xyrem is not a narcotic. Narcotics bind to opioid receptors in your brain and include substances such as codeine, oxycodone, and morphine. Xyrem contains sodium oxybate, a central nervous system depressant.
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XYWAV oral solution, 0.5 g/mL total salts (equivalent to 0.413 g/mL of oxybate) is the only FDA‑approved treatment for cataplexy and/or excessive daytime sleepiness in narcolepsy and for idiopathic hypersomnia (IH) in adults.
Xyrem starts to work after your first dose. * Typically, youll fall asleep about 515 minutes after taking it. For this reason, its recommended that you take the medication once youre already in bed. In some cases, it may take up to 2 hours after taking your Xyrem dose to fall asleep.
Both XYWAV and XYREM contain oxybate as their active ingredient, but XYWAV is a lower-sodium formulation. At the maximum recommended 9‑g nightly dose, XYWAV has 131 mg of sodium vs ~1640 mg with XYREM, a high‑sodium oxybate. This means that XYWAV has ~1509 mg less sodium per night than XYREM at the 9-g nightly dose.

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