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CASP (Critical Appraisal Skills Programme) checklists are a series of checklists involving prompt questions to help you evaluate research studies.
How to Appraise a Systematic Review Is the review question clearly and explicitly stated? Were comprehensive search methods used to locate studies? How were studies selected? Was the validity of studies assessed appropriately? Were reasons for any differences between individual studies explored?
Although meta-analysis is a subset of systematic reviews, a systematic review may or may not include a meta-analysis. An advantage of meta-analysis is that it has the ability to be completely objective in evaluating the research parameter. However, not all research areas have enough evidence to allow a meta-analysis.
Here are just some of the most common ones to consider: AMSTAR to examine the effectiveness of interventions. CASP to appraise randomized control trials, systematic reviews, cohort studies, case-control studies, qualitative research, economic evaluations, diagnostic tests, and clinical prediction rules.
Systematic Reviews and Meta Analyses Well done systematic reviews, with or without an included meta-analysis, are generally considered to provide the best evidence for all question types as they are based on the findings of multiple studies that were identified in comprehensive, systematic literature searches.
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When the included studies are judged to be significantly different on the basis of their clinical and methodological features, then meta-analysis is probably not appropriate.
Combining summary data from several studies increases the sample size, improves the statistical power of the findings as well as the precision of the obtained effect estimates. For all these reasons, meta-analyses are thought of providing the best evidence to support clinical practice guidelines.