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Motor carriers must ensure and verify that their CMV drivers meet the minimum requirements specified in 49 CFR 391 before operating a vehicle. CMV owneroperators must comply with both rules that apply to motor carriers and rules that apply to drivers.
If an employer knows, or reasonably should know, that a driver is disqualified, it must not allow the disqualified driver to operate a CMV. See 49 CFR 383.37. The disqualification period of a driver is determined by the offense and the drivers record of prior convictions.
eCFR :: 49 CFR Part 391 -- Qualifications of Drivers and Longer Combination Vehicle (LCV) Driver Instructors.
Commercial Vehicle (CVC 260)A commercial vehicle is a vehicle required to be registered which is used or maintained for the transportation of persons for hire, compensation, or profit or designed, used, or maintained primarily for the transportation of property.
49 CFR 391 explains the minimum requirements for commercial motor vehicle drivers. Motor carriers are required to maintain a qualification file for each of their drivers.

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Category 1: Non-Excepted Interstate: A person must docHub that her or she operates or expects to operate in interstate commerce, is both subject to and meets the qualification requirements under 49 CFR part 391, and is required to obtain a medical examiners certificate by 391.45.
391.41 PHYSICAL QUALIFICATIONS FOR DRIVERS (b) A person is physically qualified to drive a motor vehicle if that person: (1) Has no loss of a foot, a leg, a hand, or an arm, or has been granted a Skill Performance Evaluation (SPE) Certificate (formerly Limb Waiver Program) pursuant to 391.49.
(a) A person shall not drive a commercial motor vehicle unless he/she is qualified to drive a commercial motor vehicle. Except as provided in 391.63, a motor carrier shall not require or permit a person to drive a commercial motor vehicle unless that person is qualified to drive a commercial motor vehicle.

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