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What does p40 mean in cancer?

p40 is an excellent marker for distinguishing lung squamous cell carcinoma from adenocarcinoma, and p40 expression is equivalent to p63 expression in lung squamous cell carcinoma.

Does TTF-1 positive mean cancer?

TTF-1 has also been a useful marker for differentiating primary lung adenocarcinoma from pleural mesothelioma (37). Positive TTF-1 staining by IHC has been described in as few as 25% to as many as 80% of primary adenocarcinomas, depending on the techniques used.

What is p40 in medical terms?

p40 is an antibody that recognizes the deltaNp63 isoform of p63. This isoform may exert an oncogenic effect and is selectively expressed in squamous cell carcinoma.

What is p63 and p40?

In summary, p40 is equivalent to p63 in sensitivity for squamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma or unsuspected lymphoma as squamous cell carcinoma.