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Mutations can result from errors in DNA replication during cell division, exposure to mutagens or a viral infection. Germline mutations (that occur in eggs and ) can be passed on to offspring, while somatic mutations (that occur in body cells) are not passed on.
Which mutation is harmful to organisms? Missense mutations, nonsense mutations, frameshift mutations, deletion and addition mutations. Mutations in oncogenes are also harmful to an organism.
Types of Changes in DNA Class of MutationType of MutationHuman Disease(s) Linked to This Mutation Point mutation Insertion One form of beta-thalassemia Deletion Cystic fibrosis Chromosomal mutation Inversion Opitz-Kaveggia syndrome Deletion Cri du chat syndrome5 more rows
Mutations (changes) in the PIK3CA gene may cause the PI3K enzyme to become overactive, which may cause cancer cells to grow. PIK3CA gene mutations have been found in many types of cancer, including cancers of the , lung, ovary, stomach, brain, colon, and rectum.
(myoo-TAY-shun) A change in the usual DNA sequence at a particular gene locus. Although the term often has a negative connotation, mutations (including polymorphisms) can be harmful, beneficial, or neutral in their effect on cell function. The term variant is sometimes used as a synonym for the term mutation.
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There are four types of chromosomal mutations: deletion, duplication, inversion, and translocation. Deletion involves the loss of all or part of a chromosome. Duplication produces an extra copy of all or part of a chromosome. Inversion reverses the direction of parts of a chromosome.

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