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A family of proteins that are found on nerve cells. They are involved in cell signaling pathways that control cell growth, cell maturation, and cell survival. The genes that make the TRK proteins may have mutations (changes) that cause abnormal TRK proteins to be made.
At the cellular level, in the nervous system, expression of TrkB. FL is restricted to neurons whereas TrkB. T1 is expressed in both neurons and glia cells (Sommerfeld et al., 2000; Dorsey et al., 2006; Holt et al., 2019; Tomassoni-Ardori et al., 2019).
In situ hybridization analysis conducted with probes specific for the various trkB transcripts has indicated that gp145trkB receptors are primarily expressed in the cerebral cortex, hippocampus, and thalamus.
Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival and growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity, which is essential for learning and memory. It is widely expressed in the CNS, gut and other tissues.
The dimer of the neuronal receptor tyrosine kinase-2 (TrkB) transmembrane domains (TMDs) is a novel target for drug binding. Antidepressant drugs act as allosteric potentiators of brain-derived neurotrophic factor (BDNF) signaling through binding to TrkB.
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Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene. TrkB is a receptor for brain-derived neurotrophic factor (BDNF).

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