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What does high IL-6 indicate?

An increase in IL-6 levels has previously been observed in patients with respiratory dysfunction, implying a possible mechanism of cytokine-mediated lung damage caused by COVID-9 infection (McGonagle et al., 2020).

What does IL-6 do in rheumatoid arthritis?

IL-6 is pro-inflammatory, induces acute-phase proteins (including CRP) and contributes to the systemic manifestations of RA through hepcidin production (anaemia), its action on the HPA axis (fatigue) and its impact on bone metabolism (osteoporosis).

What is normal IL-6 range?

Results: The reported values for IL-6 in the blood of healthy donors varied between 0 and 43.5 pg/ml. The pooled estimate of IL-6 was 5.186 pg/ml (95% confidence interval [CI]: 4.631, 5.740).

What is the IL-6 pathway?

IL-6 in inflammation, immunity, and disease. IL-6 is a cytokine featuring pleiotropic activity; it induces synthesis of acute phase proteins such as CRP, serum amyloid A, fibrinogen, and hepcidin in hepatocytes, whereas it inhibits production of albumin.