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What's APLA?

Antiphospholipid antibodies (APLA) are associated with anti-phospholipid syndrome (APS), a thrombotic disorder, but they are also frequently detected in immune thrombocytopenic purpura (ITP), a bleeding disorder.

What happens in APLA syndrome?

Antiphospholipid antibodies are present in 15 - 20% of all cases of deep vein thrombosis (blood clots) and in one-third of new strokes occurring in people under the age of 50. Antiphospholipid antibodies are a major cause of recurrent miscarriages and pregnancy complications when no other causes are found.

How does APLA affect pregnancy?

Recurrent miscarriage occurs in about 1% of the general population attempting to have children (70). About 10-15% of women with recurrent miscarriage are diagnosed with antiphospholipid syndrome (71, 72). Fetal loss (\u226510 weeks of gestation) is more strongly associated with aPL than are earlier pregnancy losses (73).

How long can you live with antiphospholipid syndrome?

Results: Thirty-eight patients (15%) died during the follow-up period. Mean age of the decreased was 35.4 +/- 12.2 years (range 21-52 years) and the disease duration 8.6 +/- 8.2 years (range 0.6-20), the median length of the survival from the time of the diagnosis was 6.2 +/- 4.3 years.

How does APLA affect pregnancy?

Recurrent miscarriage occurs in about 1% of the general population attempting to have children (70). About 10-15% of women with recurrent miscarriage are diagnosed with antiphospholipid syndrome (71, 72). Fetal loss (\u226510 weeks of gestation) is more strongly associated with aPL than are earlier pregnancy losses (73).

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How does antiphospholipid syndrome cause clotting?

In APS, the immune system produces abnormal antibodies called antiphospholipid antibodies. These target proteins attached to fat molecules (phospholipids), which makes the blood more likely to clot.

What is APLA disease in pregnancy?

Antiphospholipid syndrome is an autoimmune disease. It can cause life-threatening blood clots. If you have this condition in pregnancy, your healthcare provider will watch you closely. Medicine can help reduce your risk for blood clots, but they can still happen.

Can APLA syndrome be cured?

There is currently no cure for antiphospholipid syndrome. However, treatment in the form of medication can help prevent the medical conditions antiphospholipid syndrome can cause, including blood clots and miscarriages.

Is antiphospholipid syndrome for life?

Antiphospholipid antibody syndrome (APS) has no cure. However, you can take steps to control the disorder and prevent complications. Take all medicines as your doctor prescribes and get ongoing medical care.

Can APLA syndrome be cured?

How antiphospholipid syndrome is treated. Although there's no cure for APS, the risk of developing blood clots can be greatly reduced if it's correctly diagnosed. An anticoagulant medicine, such as warfarin, or an antiplatelet, such as low-dose aspirin, is usually prescribed.

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