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Dea 254 csos 2026

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  1. Click ‘Get Form’ to open the DEA 254 CSOS in the editor.
  2. Begin with Section 1 – Applicant Information. Fill in your last name, first name, middle initial (or 'X' if none), and Social Security Number. Ensure all fields are completed accurately.
  3. Proceed to Section 2 – DEA Registration List. Enter the DEA Registration Numbers exactly as they appear on your DEA Registration Certificate (Form DEA-223). Include the corresponding names of the registered locations.
  4. In Section 3 – Applicant/Notary Signature, sign and date the application using blue or black ink in front of a certified notary public. Ensure that the notary also signs and dates the form.

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Under 21 CFR 1305.03, the completion of DEA Form 222 is required for each distribution of a schedule I or II controlled substance.
A CSOS Power of Attorney (POA) is any individual with the authority to sign controlled substance orders for a DEA Registrant. The CSOS POA applicant must have their request approved by the CSOS Coordinator for the DEA Registration number(s) being applied for.
DEAs Controlled Substance Ordering System (CSOS) is designed to provide services to DEA-registered pharmaceutical drug manufacturers, distributors, pharmacies, hospitals, and others to transmit customers orders electronically.
The DEA, Office of Diversion, E- commerce Section, operates the Controlled Substance Ordering System (CSOS) whose purpose is to issue and revoke digital signatures to DEA Registrants (manufactures, distributors, and pharmacies who order controlled substances) to digitally sign electronic orders for controlled
DEAs CSOS program allows for secure electronic controlled substances orders without the supporting paper DEA Form 222. Using a technology called PKI, CSOS requires that each individual purchaser enroll with DEA to acquire a CSOS digital certificate.

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Question: What is the MOST important consideration when executing a DEA Form 222? The supplier gets a copy of the DEA form for their records. Any errors made on the order form should be erased completely. Enter only one item on each numbered line.

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