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iPLEDGE requires TWO forms of birth control, one primary birth control and another which can be either primary or secondary. For transmasculine and non-binary individuals on testosterone, common forms of primary birth control may include an IUD, Depo-Provera shots, or Nexplanon implants.
The requirements include the patient taking pregnancy tests and using 2 forms of birth control consistently for at least 1 month prior to initiation of isotretinoin treatment, during isotretinoin treatment, and for 1 month after discontinuing isotretinoin treatment.
All isotretinoin manufacturers are part of the iPLEDGE program, and health care providers and pharmacies must be registered with iPLEDGE to be able to prescribe and dispense isotretinoin to patients.
Patients taking Accutane must register in the iPLEDGE Pregnancy Registry at 1-866-495-0654 or .ipledgeprogram.com. See your healthcare provider for further information. Accutane can cause serious mental health problems, including: depression.
Patients, their doctors and their pharmacists are required by the FDA to register and use the iPLEDGE web site in order to receive, prescribe or dispense isotretinoin.
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The iPLEDGE REMS is a, shared (includes multiple manufacturers) Risk Evaluation and Mitigation Strategy (REMS) with requirements for prescribers, pharmacies, patients, and wholesalers. The iPLEDGE REMS also includes a pregnancy registry for patients who get pregnant.
Forgot Username Please utilize the Forgot Username? link if you do not have your Username. Please utilize the Forgot password? link available for updating your password on the iPLEDGE REMS website.
At each visit, your doctor may give you a prescription for up to a 30-day supply of medication with no refills.

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