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In this study, the presence of SIRS criteria alone had no prognostic value for either in-hospital mortality or 1-year mortality. Each additional organ dysfunction increased the risk of mortality at 1 year. The authors concluded that organ dysfunction was a better predictor of mortality than SIRS criteria were.
SIRS with a suspected source of infection is termed sepsis. Confirmation of infection with positive cultures is therefore not mandatory, at least in the early stages.
Four SIRS criteria were defined, namely tachycardia (heart rate 90 beats/min), tachypnea (respiratory rate 20 breaths/min), fever or hypothermia (temperature 38 or 1,200/mm3,
The new proposal defines sepsis as life-threatening organ dysfunction caused by a dysregulated host response to infection (1-3). The new definition abandoned use of host inflammatory response syndrome criteria (SIRS) in identification of sepsis and eliminated the term severe sepsis.
Systemic Inflammatory Response Syndrome (SIRS) criteria have been used for diagnosis since 1992. The more recent attempt to replace SIRS with the quick Sequential Organ Failure Assessment (qSOFA) for assessment of potentially septic patients is troublesome.
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qSOFA has higher specificity while SIRS has higher sensitivity to shock. SIRS identifies signs of shock earlier than qSOFA, but qSOFA is a better predictor of organ dysfunction mortality.
Systemic inflammatory response syndrome (SIRS) is an exaggerated defense response of the body to a noxious stressor (infection, trauma, surgery, acute inflammation, ischemia or reperfusion, or malignancy, to name a few) to localize and then eliminate the endogenous or exogenous source of the insult.

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