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Among the 154 studies (n=3,585,911) that adopted a KDIGO-equivalent AKI definition, the pooled incidence rates of AKI were 21.6% in adults (95% confidence interval [95% CI], 19.3 to 24.1) and 33.7% in children (95% CI, 26.9 to 41.3).
The United States Renal Data System (USRDS) is a national data system that collects, analyzes, and distributes information about chronic kidney disease (CKD) and end-stage renal disease (ESRD) in the United States.
About 807,000 Americans are living with kidney failure. Kidney disease is growing at an alarming rate. It currently affects more than 1 in 7 or 15% of American adults, with people of color at greater risk for kidney failure.
Haemodialysis (HD) is the commonest form of kidney replacement therapy in the world, accounting for approximately 69% of all kidney replacement therapy and 89% of all dialysis.
In a large US population (n = 3,787,410), the community-based incidence of nonRRT-requiring AKI (defined using relative changes in serum creatinine levels) and RRT-requiring AKI (defined using integrated administrative data) was estimated at 384.1 and 24.4 per 100,000 persons-years, respectively.
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Incidence of acute renal failure was 3.1%. There were 118 (87.4%) males and average length of stay was 9 (1, 83) days. Severity of injury (ISS, GCS) was relatively more among the renal failure group. Renal failure was transient in 35 (25.9%) patients.
Nearly 808,000 people in the United States are living with ESKD, also known as end-stage renal disease (ESRD), with 69% on dialysis and 31% with a kidney transplant. Men are 1.6 times more likely to develop ESKD than women. Black people are nearly 4 times more likely to develop ESKD.
The in-hospital mortality rate for AKI is 40% to 50%, and the mortality for ICU patients is more than 50%. Other prognostic factors include: Older age. Duration of illness.

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