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Currently, there are 3 TNF- inhibitors (TNFis) Food and Drug Administration (FDA) approved for the treatment of moderate-to-severe psoria- sis: infliximab, adalimumab, and etanercept.
Clinical Criteria for Cytokine and Cell Adhesion Molecule Antagonist Drugs for Psoriatic Arthritis. Enbrel, Humira, Orencia subQ solution, Otezla, and Xeljanz are preferred drugs used to treat psoriatic arthritis.
Humira has an average rating of 6.3 out of 10 from a total of 677 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 32% reported a negative effect. Stelara has an average rating of 7.5 out of 10 from a total of 236 ratings on Drugs.com.
Skyrizi (risankizumab) can affect your bodys ability to fight off germs and raise your risk for bacterial, viral, or fungal infections. In clinical studies, people most commonly reported upper respiratory infections and fungal infections.
REMICADE belongs to a class of biologic medications known as tumor necrosis factor (TNF)-alpha blockers.

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Skyrizi and Humira belong to different drug classes. Skyrizi is an interleukin-23 antagonist and Humira is a tumor necrosis factor (TNF) inhibitor.
SKYRIZI (Sky-RIZZ-ee; skaɪ rɪz zi) is an interleukin-23 (IL-23) inhibitor that works inside the body to treat adults with moderate to severe plaque psoriasis who may benefit from taking injections or pills (systemic therapy) or treatment using ultraviolet or UV light (phototherapy) and for adults with active psoriatic
Skyrizi and Humira are both effective treatment options for plaque psoriasis. However, one study showed that Skyrizi worked better than Humira at clearing skin in people with moderate to severe plaque psoriasis.

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