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Typically, a screening test is done by an immunoassay test, be it an instant onsite test or in a lab, whereas the confirmatory test is either gas chromatography- mass spectrometry (GC-MS) or liquid chromatography- mass spectrometry depending on the specimen type being tested.
Confirmation testing takes longer to complete than screening because the instrument is looking for individual drugs and drug metabolites. Confirming positive results can take up to 24-48 additional hours after the screening results have been completed.
Urine drug testing detects evidence of recent drug use or misuse in a sample of urine. Testing can detect illegal or prohibited drug use, prescription medications, over-the-counter medicines, and legal substances such as alcohol and tobacco.
The initial test is designed to separate negative specimens from further consideration. The confirmatory test uses definitive methods, such as chromatography-mass spectrometry (e.g., GC-MS, LC-MS/MS), that specifically identify and quantify the drug/metabolite in the specimen.
What Does Initial Drug Screen Mean? An initial drug screen is a preliminary test done. If immunoassay, the most common initial screening method, is used it can only assess whether or not a specific drug metabolite is present in a sample rather than the presence of a drug itself.
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The laboratory is using chromatographic methods in combination with mass spectrometry such as Gas Chromatography-Mass Spectrometry (GC/MS) or Liquid chromatography-tandem MS (LC-MS-MS) to confirm the presence of the drug in the collected sample and determine its concentration.
Standard 12-panel test: looks for cocaine, marijuana, PCP, amphetamines, opiates, benzodiazepines, barbiturates, methadone, propoxyphene, Quaaludes, Ecstasy/MDA, & Oxycodone/Percoset.
Confirmatory urinalysis tests confirm the presence of the same analyte detected with screening tests, but offer improved sensitivity and/or specificity or confirm the result via an alternate methodology. 1. Some confirmatory tests may have been significant historically, but are less useful in today's clinical practice.
A drug test looks for signs of one or more illegal or prescription drugs in a sample of your urine (pee), blood, saliva (spit), hair, or sweat. The purpose of a drug test is to look for drug use and misuse, which includes: Using any illegal drugs, such as cocaine or club drugs.
The initial test is designed to separate negative specimens from further consideration. The confirmatory test uses definitive methods, such as chromatography-mass spectrometry (e.g., GC-MS, LC-MS/MS), that specifically identify and quantify the drug/metabolite in the specimen.

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