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It recommends initiation of statin therapy in persons with 10-year risk 7.5% (intermediate or high) and a risk discussion in persons at 5% to
MDCalc uses the Hard coronary Framingham outcomes model, which is intended for use in non-diabetic patients age 30-79 years with no prior history of coronary heart disease or intermittent claudication, as it is the most widely applicable to patients without previous cardiac events.
Risk score derivation A 10-year risk score can be derived as a percentage, which can then be used to inform the decision about initiating lipid-lowering therapy for primary prevention. Risk is considered low if the FRS is less than 10%, moderate if it is 10% to 19%, and high if it is 20% or higher.
The FRS is also limited by its lack of inclusion of other potential risk predictors of coronary disease, such as family history of premature coronary disease. A family history of premature coronary disease is a widely accepted risk factor for the development of coronary disease.
The first Framingham Risk Score included age, sex, LDL cholesterol, HDL cholesterol, blood pressure (and also whether the patient is treated or not for his/her hypertension), diabetes, and smoking. It estimated the 10-year risk for coronary heart disease (CHD).
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An individual is grouped into the high cardiovascular risk with a 10-year risk of 20% for FRS and WHO CVD, 7.5% for SCORE2 (age
The Framingham Stroke Risk Profile (FSRP) was originally described in 19911; it integrates the effect of age, sex and baseline measurements of various vascular risk factors: systolic blood pressure (SBP), use of antihypertensive medications (HTNRx), presence or absence of left ventricular hypertrophy on
Risk is considered low if the FRS is less than 10%, moderate if it is 10% to 19%, and high if it is 20% or higher.

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