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Normally, R01-type projects are mature ideas with preliminary data supporting a hypothesis. R21 projects are usually high-risk/high-reward and require a high degree of innovation. R03 projects are usually descriptive and are used to generate hypotheses and data to support them.
Activity Code (Also referred to as an Instrument Code) - A three-digit code denoting NIH research and research-related contracts. There are seven active research contract activities (N01, N02, N03, N41, N42, N43 and N44), which are listed in Table 3. Definitions of these activities are provided in Table 9.
The individual P01 research projects are each roughly equivalent in scale and scope to a NIH R01 grant, but the aim is that, together, the P01 projects produce higher synergy and address more complex scientific questions than individuals R01s.
The P01 is a confederation of interrelated research projects, each capable of standing on its own scientific merit but complementing one another. The P01 application must include a minimum of two individual research projects that contribute to the program objective.
An R01 is for mature research projects that are hypothesis-driven with strong preliminary data. R01s provide up to five years of support, with a budget that reflects the costs required to complete the project. If you have strong preliminary data supporting your hypothesis, we recommend applying for an R01.
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For institutions with relatively new research programs, NINR supports Centers focused on building research expertise and teams for the future. These Centers, awarded using the P20 Exploratory Grant mechanism, support the initial enhancement of research capacity at institutions with emerging research programs.
The R01 provides support for health-related research and development based on the mission of the NIH. R01s can be investigator-initiated or can be in response to a program announcement or request for application.
What are examples of R01 equivalent grants? R01-equivalent grants are defined as activity codes DP1, DP2, DP5, R01, R37, R56, RF1, RL1, U01 and R35 from select National Institute of General Medical Sciences (NIGMS) and National Human Genome Research Institute (NHGRI) program announcements (PAs).

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