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Common physical examination findings of rabies include hyperpyrexia alternating with hypothermia, tachycardia, respiratory collapse, hypersalivation, lacrimation, sweating, dilatation of the pupils and bradycardia. Skin findings may include percussion myoedema, bite marks and bruises.
The first symptoms of rabies, called prodrome, may be like the flu, including weakness, discomfort, fever, or headache. There also may be discomfort, prickling, or an itching sensation at the site of the bite. These symptoms may last for several days.
At first, theres a tingling, prickling, or itching feeling around the bite area. A person also might have flu-like symptoms such as a fever, headache, muscle aches, loss of appetite, nausea, and tiredness. After a few days, neurological symptoms develop, including: irritability or aggressiveness.
Diagnosis in humans Several tests are necessary to diagnose rabies antemortem (before death) in humans; no single test is sufficient. Tests are performed on samples of saliva, serum, spinal fluid, and skin biopsies of hair follicles at the nape of the neck.
The Rabies Laboratory at the CDC conducts many diagnostic tests to detect the rabies virus in humans and animals, which include: Rabies Antemortem Human Testing.
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The third stage of rabies is when neurologic symptoms occur. These are classified into 1 of 3 categories: encephalitic (also considered furious), paralytic (also considered dumb), and a rare non-classic form. The encephalitic form is most common and presents in approximately 85% of cases.

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