Xyrem prescription form 2026

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  1. Click ‘Get Form’ to open the xyrem prescription form in the editor.
  2. Begin by filling out the Prescriber Information section. Enter the prescriber’s name, office contact details, address, phone, fax, license number, DEA number, and email.
  3. Next, complete the Patient Information section. Provide the patient's name, social security number (SS#), date of birth (DOB), sex, address, contact numbers, and email.
  4. In the Insurance section, input the insurance company name and phone number. Fill in the insured’s name, relationship to patient, identification number, and policy/group number. Indicate if a prescription card is attached.
  5. For Dosing instructions, specify the total nightly Xyrem dose and split it into two doses. Clearly indicate each dose amount and ensure you follow the dilution instructions provided.
  6. Complete any Special Instructions by checking relevant boxes regarding patient education on Xyrem preparation and materials received.
  7. Finally, ensure that you sign and date the form before submitting it via fax to the Xyrem Success Program.

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XYWAV is indicated for the treatment of idiopathic hypersomnia (IH) in adults. XYREM is indicated for the treatment of cataplexy or excessive daytime sleepiness (EDS) in patients 7 years of age and older with narcolepsy.
Because of the serious risk of central nervous system depression, abuse, and misuse associated with XYREM, it is available only through enrollment in a restricted program called the XYWAV and XYREM REMS.
Doctors must become certified in the Xyrem REMS program before they can prescribe Xyrem.
An FDA-approved liquid medication for narcolepsy called sodium oxybate (Xyrem). It is a controlled substance that is about $49 a month.
Form available online at .XYWAVXYREMREMS.com. Either submit online, OR print, sign, and: Fax to XYWAV and XYREM REMS: 1-866-470-1744 (toll free) OR mail to XYWAV and XYREM REMS, PO Box 66589, St. Louis, MO 63166-6589. For more information, call the XYWAV and XYREM REMS at 1-866-997-3688 (toll free).
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The prescription drug Xyrem is the sodium salt of gamma-hydroxybutyrate (GHB). GHB has not been approved for any medical use and has the potential for abuse, such as in cases of sexual assault. GHB is a Schedule I controlled substance under the Controlled Substances Act.
Xyrem (sodium oxybate) Oral Solution is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) with an orphan disease designation to treat cataplexy (a condition where patients suddenly lose muscle tone, including voluntary muscle control, while awake) and excessive daytime sleepiness in

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