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Prescriptions for XYWAV and XYREM are only dispensed and shipped to patients who are enrolled in the REMS with documentation of safe use conditions. Each pediatric patient must have a caregiver who is counseled by the healthcare provider. XYWAV and XYREM will be dispensed only by the REMS Certified Pharmacy.
XYREM is not available at your local pharmacy. As part of the XYWAV and XYREM REMS, XYREM is available only through a Certified Pharmacy. It is the only pharmacy in the United States permitted to fill the prescription and send directly to patients.
Xyrem (sodium oxybate) Oral Solution is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) with an orphan disease designation to treat cataplexy (a condition where patients suddenly lose muscle tone, including voluntary muscle control, while awake) and excessive daytime sleepiness in ...
THE XYREM PATIENT ASSISTANCE PROGRAM (PAP) is available for those with additional financial needs. If you meet certain financial criteria, such as having a low income level, are uninsured or underinsured, you may be eligible to receive XYREM at no cost.
Prescriptions for XYWAV and XYREM are only dispensed and shipped to patients who are enrolled in the REMS with documentation of safe use conditions. Each pediatric patient must have a caregiver who is counseled by the healthcare provider. XYWAV and XYREM will be dispensed only by the REMS Certified Pharmacy.

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XYWAV is a Schedule III controlled substance. The active moiety of XYWAV is oxybate, also known as gamma-hydroxybutyrate (GHB), a Schedule I controlled substance.
XYREM is packaged in 6-ounce bottles (180 mL) with a concentration of 500 mg/mL (0.5 g/mL). XYREM is dispensed by the central Certified Pharmacy in a maximum 30-day supply for the initial fill, and a maximum 90-day supply for each refill.
Because of the risks of central nervous system depression and abuse/misuse, XYREM is available only through a restricted distribution program called the XYWAV and XYREM REMS. Notable requirements of the XYWAV and XYREM REMS include the following: Healthcare Providers who prescribe XYREM are specially certified.
Because of the risk of CNS depression, abuse, and misuse, XYWAV is available only by prescription, and filled through the Certified Pharmacy with the XYWAV and XYREM REMS. All patients must be enrolled in the XYWAV and XYREM REMS to receive XYWAV. More information about the REMS can be found at XYWAVXYREMREMS.com.
XYREM can be delivered right to your door, a local overnight carrier hub, or another location, if approved by the Certified Pharmacy.

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