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The Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) is a comprehensive 50 question assessment of both motor and non-motor symptoms associated with Parkinson's.
Results A minimal CID was 2.3 to 2.7 points on the UPDRS motor score and 4.1 to 4.5 on the UPDRS total score. A moderate CID was 4.5 to 6.7 points on the UPDRS motor score and 8.5 to 10.3 on the UPDRS total score. A large CID was 10.7 to 10.8 points on the UPDRS motor score and 16.4 to 17.8 on the UPDRS total score.
The MDS\u2010UPDRS specifically covers a greater number of PD manifestations, including nonmotor symptoms (NMS); better discriminates slight/mild manifestations of PD compared with the original UPDRS; resolves ambiguities and gives clear instructions for both raters and patients; and assesses all items in a uniform way.
3 = Severe memory loss with disorientation for time and often to place. Severe impairment in handling problems. 4 = Severe memory loss with orientation preserved to person only. Unable to make judgements or solve problems. Requires much help with personal care.
The MDS\u2010UPDRS specifically covers a greater number of PD manifestations, including nonmotor symptoms (NMS); better discriminates slight/mild manifestations of PD compared with the original UPDRS; resolves ambiguities and gives clear instructions for both raters and patients; and assesses all items in a uniform way.
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Estimates for the UPDRS total score are 4.3 points for minimal, 9.1 for moderate, and 17.1 for large CIDs. These estimates will assist in determining clinically meaningful changes in PD progression and response to therapeutic interventions.
Each parkinsonian sign or symptom is rated on a 5-point Likert-type scale (ranging from 0 to 4), with higher scores indicating more severe impairment. The maximum total UPDRS score is 199, indicating the worst possible disability from PD.
The MDS\u2010UPDRS specifically covers a greater number of PD manifestations, including nonmotor symptoms (NMS); better discriminates slight/mild manifestations of PD compared with the original UPDRS; resolves ambiguities and gives clear instructions for both raters and patients; and assesses all items in a uniform way.
UPDRS Intellectual Impairment. 0 = None. ... Thought Disorder (Due to dementia or drug intoxication) 0 = None. ... Depression. 1 = Periods of sadness or guilt greater than normal, never sustained for days or weeks. ... Motivation/Initiative. 0 = Normal. ... Speech. 0 = Normal. ... Salivation. 0 = Normal. ... Swallowing. 0 = Normal. ... Handwriting.
Estimates for the UPDRS total score are 4.3 points for minimal, 9.1 for moderate, and 17.1 for large CIDs. These estimates will assist in determining clinically meaningful changes in PD progression and response to therapeutic interventions.

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