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Platelet function platelet aggregation with atp release test

Platelet function platelet aggregation with atp release test 2025

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The document is a test request form for platelet function and aggregation tests at Children's Hospital Los Angeles. It includes sections for physician and patient information, test details, scheduling instructions, and pre-test requirements. The tests are available by appointment on specific days, with guidelines on medication restrictions and necessary documentation for the testing process.

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Does ATP cause platelet aggregation?

ATP caused platelet aggregation in rat platelet-rich plasma (PRP) but in contrast strongly inhibited ADP-induced human platelet aggregation. ADP-induced aggregation of rat platelets suspended in human plasma was strongly inhibited by ATP, whereas human platelets in rat plasma were aggregated by ADP.

What is the function of platelet aggregation test?

The platelet aggregation blood test checks how well platelets, a part of blood, clump together and cause blood to clot.

What is the role of ATP in red blood cells?

Blood (2002) 99 (1): 193198. Adenosine diphosphate (ADP) is a platelet agonist that causes platelet shape change and aggregation as well as generation of thromboxane A2, another platelet agonist, through its effects on P2Y1, P2Y12, and P2X1 receptors.

What is a platelet function test with ADP?

The platelet function analyzer (PFA)-100 or PFA-200 evaluates platelet function by measuring the time required for whole blood under high shear stress to occlude holes in a membrane coated with collagen plus epinephrine or ADP; the time to close the hole is reported in seconds.

What is the role of ATP in platelet aggregation?

Addition of ATP to whole blood resulted in platelet aggregation, the extent of which was dependent on the concentration used and was most extensive at concentrations of 10 to 100 mol/L. Increasing the ATP concentration beyond 100 mol/L resulted in a reduced aggregation response.

What activates platelet aggregation?

ATP is a major player as a signaling molecule in blood microcirculation. It is released by red blood cells (RBCs) when they are subjected to shear stresses large enough to induce a sufficient shape deformation.

What does a platelet function test diagnose?

What are they used for? A platelet count is most often used to monitor or diagnose conditions that cause too much bleeding or clotting.

Platelet function platelet aggregation with atp release test 2025

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