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A lipoprotein is a biochemical assembly whose primary function is to transport hydrophobic lipid (also known as fat) molecules in water, as in blood plasma or other extracellular fluids.
A lipoprotein (a) test measures the level of lipoprotein (a) in your blood. A high level of lipoprotein (a) may mean you have a high risk for heart disease and stroke. Lipoproteins are particles made of protein and fats (lipids). They carry cholesterol through your bloodstream to your cells.
Lipoprotein (a) is synthesized in the liver and its plasma concentration, which can be determined by use of monoclonal antibody-based methods, ranges from < 1 mg to > 1,000 mg/dL. Lipoprotein (a) levels over 20-30 mg/dL are associated with a two-fold risk of developing coronary artery disease.
Clinical Perspective The present study shows that plasma lipoprotein(a) (Lp(a)) concentration is predominantly determined by the rate of production of Lp(a) particles independent of apolipoprotein(a) isoform size and treatment with and evolocumab.
INTRODUCTION TO THE LIPOPROTEIN (a) TRAIT Lp(a) is composed of one molecule of a LDL-particle containing apoB-100 and one molecule of a large highly polymorphic glycoprotein named apo(a) (3, 4, 5, 6). A characteristic feature of apo(a) is the presence of loop-like structures called kringles (7, 8).
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According to the National Heart Lung and Blood Institute (NHLBI) report published in 2018, an estimated 1.4 billion people globally have Lp(a) levels \u2265 50 mg/with a prevalence ranging from 10% to 30% and possibly higher in patients with established atherosclerotic cardiovascular disease (ASCVD), calcific aortic valve ...
INTRODUCTION TO THE LIPOPROTEIN (a) TRAIT Lp(a) is composed of one molecule of a LDL-particle containing apoB-100 and one molecule of a large highly polymorphic glycoprotein named apo(a) (3, 4, 5, 6). A characteristic feature of apo(a) is the presence of loop-like structures called kringles (7, 8).
Plasma lipoprotein particles contain variable proportions of four major elements: cholesterol, triglycerides, phospholipids and specific proteins called apoproteins (Table 31.2).
Lipoprotein(a) [Lp(a)] is an independent, genetic, and likely causal risk factor for myocardial infarction, stroke, peripheral arterial disease,1,2 and calcific aortic valve stenosis. Circulating Lp(a) levels are largely genetically determined by a variety of differences in the LPA gene.
To achieve Lp(a) reduction, one evidence-based approach is to initiate therapy with low-dose aspirin and extended-release niacin, titrated from 0.5 g up to 2 g over several weeks.

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