Prior Authorization Request Form Genetic Testing for Lynch 2025

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IHC testing normally costs around $500. If the MLH1/PMS2 complex is not found (no methylation), it may be from Lynch Syndrome or secondary to the tumor itself. Sometimes tumors alter a protein by adding on an extra methyl group. This alters the identity and function of the protein.
The cost of the MTHFR gene mutation test varies with insurance. You can also purchase tests online for anywhere from $65 to $249, but these tests arent FDA-approved.
Genetic testing for Lynch syndrome In a family with a known Lynch syndrome mutation (MLH1, MSH2, MSH6, PMS2, or EPCAM), genetic testing is covered only for people with signs and symptoms of a Lynch-associated cancer AND a blood relative with a known Lynch syndrome mutation.
Microsatellite instability (MSI) testing. Positive IHC or MSI test results can show that the cancer cells have genetic changes that are connected to Lynch syndrome.
Note to the Ordering Health Care Provider: Some states require that patients (or their authorized representatives) provide their written informed consent prior to receiving genetic testing, and that the ordering health care provider maintain documentation of the informed consent in the patients medical record.
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