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A high score on these PROMIS short forms connotes more emotional distress (i.e., more depression or anxiety). With a standardized normative T-score of 50 and a standard deviation of 10, T-scores
For the adult PROMIS Anxiety 7a short form, a raw score of 10 converts to a T-score of 46.7 with a standard error (SE) of 2.6 (see scoring table for the 7a short form in Appendix 1). Thus, the 95% confidence interval around the observed score ranges from 40.6 to 51.7 (T-score + (1.96*SE) or 46.7 + (1.96*2.6).
The optimal PROMIS score cutoff to predict a diagnosis of a DSM-5 anxiety disorder determined by the clinical psychologist was 59 (sensitivity, 60% [95% CI, 35% to 85%]; specificity, 74% [95% CI, 60% to 89%]; PPV, 50% [95% CI, 27% to 73%]; NPV, 81% [95% CI, 68% to 95%]) (see Appendix).
The PROMIS Depression item banks assess self-reported negative mood (sadness, guilt), views of self (self- criticism, worthlessness), and social cognition (loneliness, interpersonal alienation), as well as decreased positive affect and engagement (loss of interest, meaning, and purpose).
The PROMIS Anxiety item banks assess self-reported fear (fearfulness, panic), anxious misery (worry, dread), hyperarousal (tension, nervousness, restlessness), and somatic symptoms related to arousal (racing heart, dizziness).
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The optimal PROMIS score cutoff to predict a diagnosis of a DSM-5 anxiety disorder determined by the clinical psychologist was 59 (sensitivity, 60% [95% CI, 35% to 85%]; specificity, 74% [95% CI, 60% to 89%]; PPV, 50% [95% CI, 27% to 73%]; NPV, 81% [95% CI, 68% to 95%]) (see Appendix).
Scoring and Interpretation Each item on the measure is rated on a 5-point scale (1=never; 2=rarely; 3=sometimes; 4=often; and 5=always) with a range in score from 8 to 40 with higher scores indicating greater severity of depression.
PROMIS, Neuro-QoL, ASCQ-Me, and many of the NIH Toolbox measures use a T-score metric in which 50 is the mean of a relevant reference population and 10 is the standard deviation (SD) of that population. On the T-score metric: A score of 40 is one SD lower than the mean of the reference population.
The patients answers to the PROMIS-29 are scored from 1-5 (with the exception of the NRS). The sum of the PROMIS results in the raw score, which lies between 4 and 20. There is no total score, but each axis forms its own score.
T-scores on the short form range from 0 to 81.3; 0-55 is normal, 55.1-59.9 mild, 60-64.25 moderate, and over 64.26 severe depression.

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