SimBio Virtual Labs EvoBeaker Sickle-Cell Alleles 2026

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  3. Review the introduction section carefully, as it provides crucial context about malaria and sickle-cell anemia that will aid in understanding subsequent exercises.
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Genetics. Normally, a person inherits two copies of the gene that produces beta-globin, a protein needed to produce normal hemoglobin (hemoglobin A, genotype AA). A person with sickle cell trait inherits one normal allele and one abnormal allele encoding hemoglobin S (hemoglobin genotype AS).
The usual form of hemoglobin is called hemoglobin A (HbA). Most people with sickle cell disease produce an atypical form called hemoglobin S (HbS) instead. People with HbSS have one abnormal gene from each parent that codes for HbS.

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