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[Music] hello everyone this is richard from modern healthspan today well have a look at a recent review paper from dr david sinclair which asks whether it is possible for humans to reverse age to decide on this we need to be able to measure biological age in an objective way the paper looks at some trials which have shown reversal in epigenetic age as well as explores what this means in terms of biological age here is the paper human age reversal fact or fiction chronological age does correlate with age-related diseases and conditions however it is not the best way to reflect a persons well-being or mortality risk biological age is a better way of doing this many though not all biological age clocks are based on methylation at cpg sites on the genome these methylation marks change with age in a predictable manner and provide a computational model for biological age in the last decade the age shown by these clocks has been demonstrated to correlate with age-related diseases and healt