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21 CFR part 11 sets rules for electronic records and signatures to be equivalent to paper records and handwritten signatures. This allows for the replacement of paper documentation with an electronic system to comply with FDA regulations. The focus of this video is on the requirements for signing documents electronically, including personal username and password that cannot be used by others. Companies must verify the user's identity and inform FDA of electronic signature use. Users must use a username and password for electronic signature compliance.