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Today, we are discussing column chromatography, a technique that requires working in a hood due to the use of volatile organic solvents. While we are demonstrating on a benchtop for the video, it is crucial to always work in a hood. Unlike TLC, which is analytical, column chromatography is used to obtain a substantial amount of compound by scaling it up with a packed column of silica. The process involves packing, loading, and running the column carefully.