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so this is a secondary analysis from the quantum first study and a key secondary endpoint of the quantifier study was to determine the percentage of patients who had who had achieved CR how many of those had cleared mrd how many of those were mrd negative the entire field of AML is Shifting its focus on to mrd and different techniques and a that is a question of interest just uh to start with can we use mrd in a prospective trial to predict outcome but in addition this is the first use of I think a novel approach to detecting mrd it is not flow cytometry based which is very challenging in AML despite all the controversies of whos in favor or not this is a very specific test and I want to stress its not a new test it was first developed by I think Michael hoisers group 10 years ago and used by the alpha group 3 years later and used by two other groups a few years later to look at very specific Flip 3 idd specific mrd crngs its a double assay and you can actually order the assay uh