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good afternoon my name is ben delaio im a senior research fellow at curtin university in perth australia and today ill be talking to you about our ammf funded study twerk fm14 signaling promotes calanger carcinoma niche formation and progression so a number of alterations occur in cancer cells themselves which drive cholinergic carcinoma tumorogenicity however theres been increasing focus on the tumination cholangiocarcinoma which consists of the supporting microenvironment of cells and molecules which drive tumor genetic tumor genic characteristics interactions between tumor cells and the niche are especially important in disease progression metastasis and therapy resistance were interested in an important immune cell type of this niche the macrophage so tumor-associated macrophages or tams are one of the most abundant immune cell types in chlangiocarcinoma and theyre docHub because the presence of a specific type of macrophage is associated with worse patient outcomes there