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[Music] lets talk a little bit about the idea of effect modification now this also gets known as interaction or sometimes moderation interaction is usually the term used when looking at predictive modeling rather than effect size modeling but quite often theyre used interchangeably moderators one youre here less often but effect modification or sometimes interaction is the term here for this now what this is it suggests that the effect that x1 has on y right b1 that depends on another variable which were going to call x2 where we can think of it is that we need to have multiple b1s right we need to have multiple multiple coefficients the effect that x1 has on y depends on x2 depends on some other variable or its modified by that other variable so in health research quite often age sex and race are quite common to be effect modifiers or at least ones worth exploring in a moment ill write down some of the criteria i just want to think through some examples of what an effect modific