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In this video, the speaker explains the concepts of ESD, UniGene, and transcript, and highlights the differences among them. These terms are related to gene expression, critical for understanding an organism's health and disease. Techniques such as microarray and transcriptome sequencing provide information about gene expression. ESDs, ESTs, and UniGene represent the expressed part of the genome through short DNA sequences. Genes are not always expressed, and they are turned on and off in response to environmental cues. Watch the previous video for more information on reads, contigs, and scaffolds.