Regulate formula transcript easily

Aug 6th, 2022
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How to regulate formula transcript

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Voiceover: So what makes a cell thats located inside of your nose responsible for smelling, say, a slice of pizza look and act differently from a cell that lines your gut and is responsible for absorbing the nutrients from that pizza? They have the exact same DNA so the differences cant be attributed to that fact alone. The answer actually lies in the expression of that DNA, which genes are actively transcribed and which ones arent and there are several ways in which gene regulation occurs at the level of transcription and so were going to be talking about the main ones here. Now lets draw out a hypothetical gene here and associated with this gene is a sequence upstream so towards the three prime region of the antisense strand, also called the template strand. And this sequence is called the promoter and there is another sequence in between the promoter and the gene called the operator. The operator is the sequence of DNA to which a transcription factor protein combined and the p

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It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators.
Transcription factors are essential for the regulation of gene expression. Under the effect of transcription factors, the various cells of the body can function differently though they have the same genome.
Transcription factors that are activators boost a genes transcription. Repressors decrease transcription. Groups of transcription factor binding sites called enhancers and silencers can turn a gene on/off in specific parts of the body.
Gene expression is regulated by lncRNAs at multiple levels. By interacting with DNA, RNA and proteins, lncRNAs can modulate chromatin structure and function and the transcription of neighbouring and distant genes, and affect RNA splicing, stability and translation.
Certainly, the most well characterized regulatory small non-coding RNAs in human cells have been the ability of the miRNAs to regulate gene expression in a post-transcriptional manner. Functionally, these miRNAs bind their target mRNAs, via homology dependent interactions.
As these RNAs are transcribed from non-coding DNAs they are referred to as non-coding RNAs. Evidence has begun to emerge suggesting that non-coding RNAs can functionally alter gene expression in a manner that is both directly targeted as well as long-lasting.
First, transcription is controlled by limiting the amount of mRNA that is produced from a particular gene. The second level of control is through post-transcriptional events that regulate the translation of mRNA into proteins. Even after a protein is made, post-translational modifications can affect its activity.
Transcriptional regulation is a critical biological process that allows the cell or an organism to respond to a variety of intra- and extra-cellular signals, to define cell identity during development, to maintain it throughout its lifetime, and to coordinate cellular activity.

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