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YouTube Red, not mentioned in the main video, is YouTubes second source of income that avoids the whole advertiser auction by getting viewers to pay monthly to hide the ads and get access to exclusive content. YouTube keeps the exact split of revenue a secret, only saying that creators get a majority, but whatever that percent is, that portion of the money collected from subscribers is divided among all creators based on what percent of total time on YouTube their videos are watched. Doing a very ballpark estimate, channels with short videos might get around 5% additional revenue from Red, and channels with really long videos that are watched might get 40 to 50% more. Its worth noting that per view a YouTube subscriber is worth more to both YouTube and creators, not just in dollars, but also in stability. Their monthly payments are predictable unlike the ad auctions, So, it shouldnt be a surprise if YouTube continues to try to turn more subscribers and countries Red.

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What are post approval changes to drug substance?

Post Approval Change services include: Changes like deletion of the manufacturing site involved in the manufacturing of the product. Services like changes in the manufacturing process, packaging, labelling, or documentation pertaining to the product.

What is the annual drug notification process?

The Annual Drug Notification Form (ADNF) is intended to assist manufacturers in complying with section C. 01.014. 5 of the Food and Drug Regulations which requires that every manufacturer of a drug confirms annually before October that all information previously supplied with regard to that drug is correct.

What is a notifiable change?

Level II or Notifiable Changes (NC) are changes to a new drug that have the potential to impact the safety, efficacy, quality and/or effective use of the drug but do not require the issuance of a NOC.

What is post noc level iii changes?

A Level III change is defined as any change to the label that is not expected to impact the safety, efficacy, and/or effective use of the drug. The changes included in this reporting category may be implemented by the sponsor without prior review by Health Canada of the data supporting such a change.

What is C 01.014 3 of the Food and Drug Regulations?

01.014. 3 of the Food and Drug Regulations, the manufacturer has the obligation to notify Health Canada when they first sell a drug that has been issued a DIN. A manufacturer must return a completed DNF to Health Canada within 30 days of first selling the drug. The DNF must be filled out, signed, and dated.

What is notice of compliance?

A Notice of Compliance (NOC) is issued to a manufacturer following the satisfactory review of a submission for a new drug, and signifies compliance with the Food and Drug Regulations.

What is post noc?

After a new drug as defined in section C. 08.001 of the Food and Drug Regulations has been granted a Notice of Compliance (NOC), it is not uncommon for sponsors to make changes to the drug. A post-NOC change is any change that is made to a new drug that has received a NOC pursuant to section C.

What is a non vs NOD?

The difference between a NOD and a NON is that the review of the submission is not complete when a NOD is issued. The Response to a Notice of Deficiency is to be submitted within 90 calendar days from the date the NOD was sent.

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