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there are a lot of factors that seem to contribute towards people getting Alzheimers disease there are unmodifiable risk factors like older age and genetics and then theres modifiable risk factors some will say that lack of exercise too much alcohol social isolation or poor quality of relationships lack of quality sleep all of these play a part but if someone asks me what is the single most important contributor the answer at this point especially with all the recent research thats come out seems pretty obvious and thats eating too much sugar which really is a simple way of saying that at the molecular and cellular level its a problem with insulin resistance inflammation and oxidative stress which ends up impairing mitochondrial function insulin resistance can lead to mitochondrial dysfunction anywhere in the body but the last place that you want it to happen is in your neurons but in Alzheimers disease thats exactly what happens and it starts in the neurons that make up your h