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The tutorial compares setting a document password in Nuance Power PDF and Adobe Acrobat DC. In Adobe Acrobat, you click on "protect," then "encrypt," and "encrypt with password," input the password, and save the document. In Nuance Power PDF, you go to the security tab, click on "manage security," select "password security," and set up the password. Both programs require saving the document afterward to make the changes permanent.