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In this Stat Quest video, Josh Stommer explains the main concepts of principal component analysis (PCA) in a concise five-minute tutorial. He uses the example of analyzing normal cells' gene expression to illustrate how PCA can help identify differences between different types of cells based on their gene activity. By sequencing messenger RNA, researchers can gain insights into what each cell is doing, similar to measuring weight or blood pressure in people. If you want more details, check out his other PCA video.