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a new paper published on the 8th of march this year showed a 17 increase in lifespan when the researchers blocked an enzyme called cd38 cd38 it gobbles up a molecule called nmn which many people already take as a supplement to extend their health span so in this video well go through the background research on cd38 how it relates to nmn supplements and then well have a deep dive into the new paper lets get into it at the center of our metabolism is a molecule called nad and nad is vital for a number of different processes in our body so for example theres a class of enzyme called parps which are critical for dna repair but weve got very good human data showing that as we age our levels of nad go down so this was confirmed in a february 2022 paper this likely means that our metabolism is not as resilient compared to our younger days and its why many people myself included take supplements to boost our nad levels but that begs the question why does nad go down and that brings us o
