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In this StatQuest tutorial, Josh Stommer discusses the main ideas behind principal component analysis (PCA) in five minutes. He explains how normal cells, which could represent people, cars, or cities, may look the same but have differences that can be identified by sequencing messenger RNA to determine active genes. This information helps to understand what the cells are doing, similar to measuring weight, blood pressure, and reading level in people. If more details are needed, viewers are encouraged to check out his other PCA video.