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I would like to turn to mention one thing about disease monitoring we spent a lot of time talking about checking bc are able levels via International standardized testing on an every three month basis but what happens when theres been a slight change in PCR results how worked up should i get if i see a patient who has gone from from point 1 to point 2 when when would you bring that patient back maybe they all start with you yeah so fluctuations in my experience happen quite frequently and unfortunately they cause a fair amount of alarm to patients I the worst in my opinion of those patients who fluctuate between being undetectable or maybe weakly positive to being quantifiable because you dont really you dont really know how far below detectable they were and so but but thats always you know the source of great concern email is that because youre going to look for a true change as a log increase yeah so if theyve gone from undetectable to detectable you dont know if theyve had