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cleaning the atr crystal is one of the most common questions we get its important that when you clean the atr crystal you make sure that you squirt the solvent directly onto the chem wipe and not the atr this is important because most of those solvents are highly volatile when you wipe it off and dry it those volatile gases are still in the air and the atr can catch those that may change then from your background to your sample causing you to get either positive or negative going peaks usually we suggest that you clean your atr with ipa or methanol or one of those types of solvents to clean the crystal go ahead and squirt the ipa onto the chem wipe youre going to want to clean the crystal in an outward fashion so start in the middle and do a circular outward fashion this pushes any kind of sample that may have been on the crystal to the outside of that crystal once youve cleaned it go ahead and take a dry chem wipe and dry off that crystal thats it