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Skin. Another thing on a long list of things that amoebas dont have but greatly admire because skin, which is your largest organ, is remarkable. Being the largest organ, its very fitting that its party of a system with a very long word: integumentary system. Skin - and structures associated with it make up the integumentary system. Why do we admire skin so much? Well, skin is critical for homeostasis because it helps maintain internal body temperature and fluid balance. As a physical barrier, it protects your internal structures and organs from being damaged. It protects from invasion of pathogens like bacteria or fungi for example. Skin is where Vitamin D is produced. Skin also has sensory functions for example, if a ladybug lands on your arm, you are usually aware of it. The integumentary system, which includes skin, has some depth to it: this system has layers. Layers of different tissues and cell types. And youll find major layers can be di