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welcome to the second session which is entitled what can we learn from cancer genomes about rare diseases so its my very great pleasure to invite professor sir mike stratton whos director of the welcome trust sanger institute to deliver the first luptsky lecture and mikes going to talk to us this morning about signatures of mutational processes thank you very much helen and thank you very much to the organizers for inviting me and for the privilege of delivering the jimnapski lecture named after well my colleague and friend jim lupsky and really thats a great privilege thank you very much most of us subscribe to the notion that all cancers are caused by somatic mutations but actually we have a relatively rudimentary view of what are the causes of those somatic mutations that cause cancer and thats really rather remarkable because of course those causes of somatic mutations are indeed the causes of cancer at a very high level we recognize that somatic mutations take place in all c