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[Music] well cgrp evolutionarily has been there for 450 million years since the cambrian period fish have cgrp reptiles so one thing is if evolution deems cgrp so crucial in every organ system we we cant ignore evolution we ignore it at our peril and looking head to toe cgrp does some bad things like for migraine creates inflammation but it does a whole lot of good things and blocking it leads to side effects that weve seen constipation anxiety joint pains and muscle pains many serious ones such as stroke or what we call rcvs ive seen in my my clinic uh the area posterima syndrome with severe severe nausea and vomiting and weight loss or weight gain and hair loss and depression so theres been a smattering of others uh right now as of um three years after these came out we have almost 50 000 reports to the fda now those are adverse events so were not completely sure that their adverse effects which is from the drug and we have almost 7 000 serious side effects serious is hospitali