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[Music] so that weve talked about you know what does a normal PSA weve talked about PSA density can you talk about PSA velocity or doubling time right so in the early years when PSA was all we had were talking about back in the 1990s we didnt have these fancy scans we didnt have OpCo we didnt have select MDX and so there were attempts made to look at how fast the PSA is changing it makes sense because if there was a bad cancer youd figure its growing faster the PSA would be rising more quickly and that might be a good indication as to whether theres a bad cancer behind all this PSA activity turned out that it didnt work for well it sounds great on paper but the problem is theres so many other reasons that PSA jumps around that rapid rises in PSA were oftentimes occurring for from prostatitis so someone could have cancer and prostatitis so they could have cancer and you know nonspecific inflammation or lab variations and there just wasnt any added precision in the decision