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Marina DiStefano, a clinical molecular genetics fellow at Harvard and postdoc in ClinGen, presents a three-part training series on transcript annotation and curation. Part 1 focuses on the importance of transcript curation in the hearing loss clinical domain, providing an overview of transcript annotation bodies and their differences. Gene curation is essential for variant curation, as the effect of a variant on a gene cannot be determined if the gene is not associated with a disease. Part 2 explores transcript curation resources, and part 3 discusses a specific transcript curation strategy used in the hearing loss domain.