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Marina DiStefano, a clinical molecular genetics fellow at Harvard, discusses the importance of transcript annotation in part one of a three-part series. Transcript curation is essential for identifying the impact of gene variants in disease. The series will cover different aspects of transcript annotation and curation, focusing on the hearing loss clinical domain. Gene curation is necessary for variant curation to determine the effect of variants on genes associated with disease. This series will provide an overview of transcript annotation bodies and strategies deployed in the hearing loss domain.