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Marina DiStefano, a clinical molecular genetics fellow at Harvard, introduces a three-part training series on transcript annotation and curation. Part 1 focuses on the importance of transcript curation, using examples from the hearing loss clinical domain. It also covers different transcript annotation bodies. Gene curation is necessary for variant curation, as the effect of a variant on a gene cannot be determined without it. Parts 2 and 3 will delve into more resources and specific strategies in transcript curation.