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A 2016 study revealed that 14 out of 16 participants from The Biggest Loser regained most of the weight lost. Contrary to popular belief, it wasn't due to lack of effort or exercise. The show's creators and scientists discovered that metabolic adaptation to lower body weight was significant. For instance, someone who lost weight from 300 pounds to 150 pounds may burn significantly fewer calories than expected, causing challenges with weight maintenance. Adaptation of thermogenesis and alterations in brain hormones played a key role in weight regain.