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Age-related macular degeneration is a main cause of adult blindness globally. This disease affects the macula in the eye, with the choriocapillaris supplying oxygen and nutrients to the outer retina. Vitamin A is crucial for photoreceptor function, being converted to 11-cis retinal by RPE cells. Damage to RPE cells in AMD leads to cholesterol secretion, forming deposits in Bruchs membrane and between Bruchs membrane and RPE cells. These deposits contain cholesterol, impacting normal night vision.